The global oral thin film market is projected to reach US$ 3.7 billion by 2024 and further increase at a CAGR of 8.9% to reach a size of US$ 8.7 billion by 2034. Oral thin films are oral strips made in an ultra-thin form factor that dissolves or disintegrates within seconds in the mouth. These are alternatives to various traditional oral dosage forms like tablets, capsules, and others.

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What is an Oral Thin Film Product?

Oral thin films are offered as a drug delivery system that would dissolve or disintegrate readily in the mouth without water intake. The films, typically placed on the tongue or inside the cheek, dissolve to release the active pharmaceutical ingredient. They are thin, flexible strips that can carry a wide range of drugs—over-the-counter medications, prescription drugs, and nutraceuticals. OTFs present an alternative dosage form to traditional dosage forms like tablets, capsules, and liquid forms.

Advantages of Oral Thin Films

Oral thin films have several advantages over conventional dosage forms:

Ease of Administration: Due to the difficulty of swallowing, OTFs are more useful for populations such as pediatric, geriatric, and psychiatric patients. The ease of administration without water makes them very convenient for on-the-go use.

Rapid Onset of Action: Since it gets dissolved quickly inside the oral cavity, the drug gets absorbed very fast into the systemic circulation, which exerts a faster onset of action compared to conventional tablets or capsules.

Improved Patient Compliance: Easy administration and the pleasant taste of many OTFs improve patient adherence to medication regimens.

Accurate Dosing: OTFs provide ultra-precise dosing and reduce the potential for dosing errors associated with liquid medications.

Avoidance of First-Pass Effect: Some drugs administered via OTFs can avoid hepatic first-pass metabolism, increasing bioavailability and efficacy.

Polymers Used in Oral Thin Films

The OTFs are prepared using various polymers to achieve the mechanical property, solubility, and drug release characteristics as per the need. Some commonly used polymers are mentioned below:

Hydroxypropyl Methylcellulose: HPMC is commonly used because of its excellent film-forming property and solubility in water, producing transparent and flexible films.

Pullulan: It is a naturally occurring polysaccharide popular due to its good film-forming ability, low toxicity, and excellent solubility.

PVA: The synthetic polymer possesses film-forming ability, flexibility, and resistance to moisture.

Sodium Alginate: It is extracted from brown algae and used for its film-forming properties with biocompatibility features.

Gelatin: This natural polymer finds its place in some of the formulations of OTF due to its film-forming property and biodegradation ability.

Oral Thin Films Market Size

The oral thin film market has grown multifold in just a decade because of increasing consumer preference for fast, hassle-free, and result-driven pharmaceutical delivery. According to Fact.MR, the oral thin film market is forecasted to rise continuously owing to several factors:

Growing Demand for Pediatrics and Geriatrics Pharmaceuticals: The increasing population of children and the elderly, globally, who have difficulty in swallowing conventional dosage forms acts as a major driver of this market.

Technological Advancements: Advancements in polymer science and techniques used for the formulation of drugs increase the efficiency of OTFs and broaden their range of applications.

Increased Focus on Patient-Centric Care: With increasing emphasis by healthcare providers and pharmaceutical firms on patient-centric care, the trend has been toward user-friendly drug delivery systems, of which OTFs are one example.

Growth in Over-the-Counter Products: With growth in the OTC segment of medications, there has been corresponding development and commercialization for a wide range of therapeutic areas, including pain relief, allergy, and dietary supplements in OTF products.

North America is likely to account for the highest share in the market on account of a high spend on health care, advanced infrastructure for health care, and the presence of major companies in the pharmaceutical industries sector. However, the highest growth rate is expected in the Asia-Pacific region owing to increasing awareness about healthcare, rising disposable incomes, and increasing pharmaceutical manufacturing capacities.

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Conclusion

The oral thin film market is likely to show exponential growth with rising demand for drug delivery systems that are easy to use and possess effective properties. These several advantages of OTFs, such as ease of administration, rapid onset of action, improved patient compliance, accurate dosing, and the possibility of avoiding the first-pass effect, make them very attractive for several patient populations. Innovative polymers in OTF formulations continue to aid in enhancing their efficacy and improving their range of applications. Based on the recent market trends, in the near future, the oral thin film market is bound to grow much more with continued technological innovations and a patient-centric model of care.

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